Pointing at Ito cell, from structure to function or Cinderella story in liver histology Adriana Grigoras, Simona Eliza Giusca, Elena Roxana Avadanei, Cornelia Amalinei, Irina-Draga Caruntu For more than years, the hepatic stellate cells also known as Ito cells have been the object of numerous studies that aimed at their characterization both in normal and postlesional status, where they play a key role in psa density md calc progression specific for chronic hepatic pathology.
Converged studies on their histophysiology have revealed other functions, namely the involvement in liver embryological development and regeneration, metabolisms regulation, modulation of local inflammatory and immune reactions.
Ito cells plasticity is surprising, as they are able to provide the connection between the complex sinusoidal and parenchymal microenvironment, influencing by autocrine and paracrine mechanisms the extracellular matrix content in tight correlation to growth and repair necessities. Last but not least, Ito cells take an active part in systemic homeostasis maintenance by their capacity to store and mobilize vitamin A, respectively.
The evolving interest in their research will be undoubtedly followed by a better knowledge of the physiopathological sequences psa density md calc for liver diseases, as new targets for the development of new therapeutic approaches directed toward improvement of prognosis and patients quality of life. The utility of bone remodeling markers in the diagnosis, evolution and treatment response evaluation in bone metastases Mihail-Lazar Mioc, Horia George Haragus, Andrei Dan Balanescu, Pompiliu Horatiu Petrescu, Mihaela Iacob, Radu Prejbeanu After the lungs and liver, the bone is the third most common site for metastatic disease, appearing frequently in breast and prostate malignancies.
These pathological bone events that occur during the evolution of the metastatic disease are usually the onset of osteolysis and they lower the patient s life quality, and are sometimes the cause of death due to the required treatments surgery, radiotherapy.
Due to the nature of the bone remodeling process, psa density md calc markers that control bone resorption are the main early indicators of bone malignancy. Analyzing these indicators in conjunction with traditional tumoral markers such as the prostate specific antigen PSA and the type I collagen cross-linked telopeptide ICTP can often increase the sensibility of the investigation and psa density md calc chances of diagnosing bone metastases.
The studies that were carried out in order to research this area of knowledge have had good and expected results.
Mesuring volumetric mass DENSITY - Relative DENSITY (specific gravity) - PCCL Physics - Matter
Most of the efforts are now channeled into developing a better therapeutic strategy that would allow for the early diagnosis and treatment of the pathological bone events. Until these markers can be used as standard investigation methods in all of our patients, some controlled studies must be carried out in order to statistically prove these results, which are purely observational.
Narrow band imaging endoscopy for detection of precancerous lesions of upper gastrointestinal tract Dan Nicolae Florescu, Elena Tatiana Ivan, Adriana Mihaela Ciocalteu, Ioana Andreea Gheonea, Diana Rodica Tudorascu, Tudorel Ciurea, Dan Ionut Gheonea Gastric cancer GC is an important health problem despite the advances in surgery and chemotherapy and although the incidence is decreasing, GC is still considered the second most common cause of deceases produced by cancer.
Survival rates in gastric cancer are low, mainly because most patients psa density md calc often diagnosed in late stages. The current interest in the diagnostic of GC is the detection of early gastric cancer. Advances in high-resolution endoscopic techniques such as narrow band imaging NBI allow the detection of early precancerous lesions like polyps or metaplastic mucosa.
Performing only white light imaging endoscopy in tratamentul prostatitei în suburbii to psa density md calc density md calc gastric cancer can lead to omission or misdiagnose of a considerable number of early gastric cancers.
NBI endoscopy associated with other high-resolution examinations is viable in detecting early gastric cancer, though few studies also indicate that the endoscopist s expertise plays an important factor as well.
Histopathological aspects in autoimmune cutaneous manifestations associated with hepatitis C virus infection Laura Statescu, Dan Vata, Delia Ciobanu, Laura Gheuca Solovastru, Maria Rotaru Autoimmunity is characterized by activation of the immune system that attacks and destroys wrongly, the body s own structures. All body tissues can be affected erythrocytes, leukocytes, platelets, blood vessels, muscle tissue, endocrine system, and otherincluding the skin.
Autoimmune diseases have an increased frequency in women, especially in adulthood, and they are associated with hereditary factors. Although the etiology of autoimmune diseases is incompletely elucidated, there is an association between chronic infection with psa density md calc C and autoimmunity, association highlighted and well documented in clinical studies. Other viral infections do not have the same connotation in the context of autoimmunity, but it is recognized that they are an important triggering factor in the pathophysiological mechanism.
The cases associating chronic hepatitis C treated with interferon and ribavirin, with multiple autoimmune diseases substrate, raising the discussion of a possible pathophysiological correlation between them.
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In the last 40 years, there was observed a rapid increase of their incidence, because of the UV radiations exposure and weather changes. Although its morbidity is a relatively modest one, the direct social costs of NMSCs are quite substantial due to a high incidence. Due psa density md calc these reasons, numerous studies try to clarify the etiopathogenic mechanisms of NMSCs, to elaborate treatment and prevention measures. In the last years, a special attention was given to the relation between inflammation and skin cancer.
In our study, we performed a histological and immunohistological evaluation of the inflammatory reaction on a number of 73 surgical exeresis pieces coming from the patients diagnosed with NMSCs.
The journal is coordinated by an Editorial Board consisting of national and international recognized specialists, researchers, professors, and experts from governmental organizations. The articles are scientifically revised by two national and international experts in the field, from research institutes or universities.
The peritumoral inflammatory reaction in NMSCs was an extremely variable one in intensity and distribution, from one case to another and even from one area to another within the same tumor, thus proving the complexity of the relations between tumor cells and the cells of the immune system. By comparing the intensity of the inflammatory reaction between the two main types of NMSCs, there was observed that in SCCs the inflammatory reaction was more intense in comparison to BCCs. Also, in SCC there was highlighted a more abundant inflammatory infiltrate in poorly differentiated carcinomas, in psa density md calc to the well-differentiated ones.
The presence of the immune system cells T-lymphocytes, macrophages, mast cells among the tumoral cells, in a direct contact with these, makes us believe that between the two categories of cells there may appear mechanisms of intercellular communication, distinct from the mechanisms of paracrine signaling. Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury Raluca-Stefania Fodor, Anca-Meda Georgescu, Bianca-Liana Grigorescu, Adrian-Dan Cioc, Mihaly Veres, Ovidiu-Simion Cotoi, Pal Fodor, Sanda-Maria Copotoiu, Leonard Azamfirei Objective: The objective of this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand FasL correlates with regim alimentar prostata dose- and time-dependent severity of lung injury, induced by the administration of lipo-polysaccharide LPS in an endotoxemic rat model.
We measured FasL plasma levels of the rats at different time points and analyzed the relationships with markers of lung injury. To investigate the level of caspase 3-protein expression, the immunohistochemistry of the lung tissue was assessed.
The prognostic and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories Laura Alexandra Nussbaum, Lavinia Maria Hogea, Nicoleta Ioana Andreescu, Prostatitis cronica tratamiento quirurgico Claudia Gradinaru, Maria Puiu, Andrei Todica We approach an integrated, multidisciplinary, innovative research-action model in children and adolescents with psychosis and ultra high-risk categories.
Our main focus was: to investigate the prognostic and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories; the dynamic evaluation of the clinical evolution psa density md calc the studied groups in correlation with specific neurobiological and neuroimagistic variables and markers. Our research was conducted in the period on 87 patients, children and adolescents with psychosis 42 took treatment after pharmacogenetic testing, 45 without and 65 children with ultra high-risk UHR for psychosis - 32 benefited of pharmacotherapy after pharmacogenetic testing and 33 without.
Also, the patients were evaluated through magnetic resonance MR spectroscopy at baseline and after pharmacotherapy.
Our results, showed statistically significant differences of the clinical scores between the studied groups. Our research was a proof, sustaining the use of the pharmacogenetic testing in clinical practice and the value of investigating relevant neurobiological and neuroimagistic markers for a personalized, tailored therapy for psychotic patients and neuro-psychiatric UHR categories, as a fruitful pathway of intervention and care.
Psa density md calc author: Lavinia Maria Hogea; e-mail: laviniahogea yahoo. Afterwards, their tissue distribution was established: white and brown adipose tissue, central nervous system, myocardium atrial and ventricularblood vessels, smooth gastrointestinal muscles stomach, small intestine, colongallbladder, urinary bladder, prostate, skeletal muscles. Non-clinical trials have demonstrated the major implication of beta3-ARs in glucose metabolism, implicitly, in insulin release, and also in obesity.
After 14 days of treatment, glycemia and enzymes involved in homeostasis of glucose metabolism, glucosephosphate dehydrogenase G6PDglucosephosphatase G6Pase and hexokinase were determined. Results and Conclusions: Glycemia in animals treated with the tested compounds decreased statistically significant for groups C2 and C3 C2 was also the compound to favorably modify the dynamics of determined enzymes, together with the display of very good safety profile supported by minor, non-significant, histopathological changes.
We aimed to identify the optimum morphological characteristics that best describe a polyp and convert them into feature vectors used for automatic detection of polyps present in images acquired by wireless capsule endoscopy WCE. We prospectively included 54 patients with clinical indications for WCE. Initially, physicians analyzed all images acquired, identifying the frames that contained small bowel polyps.
Subsequently, all images were analyzed using an automated computer-aided diagnostic system designed and implemented to convert physical characteristics into vectors of numeric values.
The data set was completed with texture and color information, and then analyzed by a feed forward back psa density md calc artificial neural network ANN trained to identify the presence of polyps in WCE frames. Overall, the neural network had In comparison, physicians diagnosis indicated Computer-aided diagnostic of small bowel polyps, based on morphological features detection methods, emulation and neural networks classification, seems psa density md calc, fast and reliable for physicians.
Lectin purification from carp roe Cyprinus carpio L. That allowed obtaining lectin with electrophoretic purity and yielding of cca. The de ce ma doare jos cand urinez lectin was thermostable, withstanding heating to 75 degrees C for 15 minutes, without noticeable loss of hemagglutinating activity.
CCRA showed the best agglutination titer with pigeon erythrocytes, weaker - with rabbit and dog erythrocytes, and significantly weaker - with human and rat erythrocytes. The best lectin activity inhibition possessed alkaline phosphatase of calf psa density md calc and fetuin. A comparative study on the histochemical specificity of CCRA and PHA-E using specimens of normal tissues, and that of colon neoplasia, showed similar, yet not identical binding properties.
CCRA lectin rather differentially labeled adenoma and adenocarcinoma of colon, which suggests its prospective applicability in diagnostic histopathology. Morphological, imaging and surgical aspects in endometrial endometrioid adenocarcinoma Costin Berceanu, Alex Emilian Stepan, Claudia Mehedintu, Monica Mihaela Cirstoiu, Razvan Ciortea, Sabina Berceanu, Ioana Andreea Gheonea, Elvira Bratila Endometrioid endometrial adenocarcinomas EECs are frequent genital tumors for which the clinical, imaging and histopathological integrated analysis is the basis of differential diagnosis and therapeutic attitude.
This research represents a tertiary multicenter study including 58 cases examined histopathologically and immunohistochemically, surgically treated, on a five years period.